2-NAPHTHYLVINYL KETONE

Name	ZM 449829
Synonyms	ZM 449829 JAK3 INHIBITOR V 2-Acrylonaphthone 2-NAPHTHYLVINYL KETONE 1-Naphthalen-2-yl-propenone 1-(2-Naphthyl)-2-propen-1-one 1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE 2-Propen-1-one, 1-(2-naphthalenyl)-
CAS	4452-06-6

Molecular Formula	C13H10O
Molar Mass	182.22
Density	1.093±0.06 g/cm3(Predicted)
Boling Point	319.3±15.0 °C(Predicted)
Appearance	Morphology White waxy solid
Storage Condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Physical and Chemical Properties	Bioactive ZM 449829 is an effective, selective and ATP competitive JAK3 inhibitor with pIC50 value of 6.8. ZM 449829 is a pharmacological tool that can be used to study JAK3.

Raw Materials

in vitro study

ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC 50 =5.0) , Jak1 (pIC 50 =4.7), and tyrosine kinases Lck and CDK4 (pIC 50 <5.0).

ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation.

Western Blot Analysis

Cell Line: YTS, NK92, and ex vivo NK cells

Concentration: 1 μM

Incubation Time: 30 minutes pretreatment

Result: Inhibits the phosphorylation of STAT5.

Last Update：2024-04-09 21:54:55

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CAS: 4452-06-6
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Product Name: ZM 449829 Visit Supplier Webpage Request for quotation
CAS: 4452-06-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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2-NAPHTHYLVINYL KETONE

Raw Materials for 2-NAPHTHYLVINYL KETONE

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